PMC

(A) A section from the inoculation site in the left hind leg in mink inoculated with A. phocae and novel Streptococcus sp. s.c./i.d. shows acute, severe superficial and deep, diffuse neutrophilic inflammation. (B) Severe haemorrhage and diffuse neutrophilic inflammation is seen in the inoculation site in mink inoculated solely with A. phocae s.c./i.d. (C/D) A skin section from the mink inoculated with A. phocae and novel Streptococcus sp. shows sub corneal pustular inflammation with haemorrhages. (E) More deep diffuse neutrophilic inflammation is demonstrated in picture E from skin section from the mink inoculated with A. phocae s.c./i.d. (F) Severe necropurulent inflammation is seen in mink inoculated s.c./i.d. with tissue extract of FENP affected mink. (G) Similar inflammation is seen in mink inoculated with A. phocae. (H/I) Skin section from the control mink injected s.c./i.d. with NaCl solution showed no histopathological lesions.

Histopathologic appearance of the tissues of the experimental mink. (D1) Lung tissue taken from a mink died from K. pneumoniae-SD-12 infection on days 5 p.i., characterized by bleeding and congesting of the lung breakage. (D2) Lung tissue taken from a mink died from K. pneumoniae-SD-21 infection on days 5 p.i., characterized by bleeding of the lung breakage. (D3) Lung tissue from a euthanized mink inoculated with 0.9% NaCl solution on days 5 p.i. (E1) Liver tissue taken from a mink died from K. pneumoniae-SD-12 infection on days 5 p.i., characterized by congesting and steatosis of the liver breakage. (E2) Liver tissue taken from a mink died from K. pneumoniae-SD-21 infection on days 5 p.i., characterized by congesting and steatosis of the liver breakage. (E3) Liver tissue from a euthanized mink inoculated with 0.9% NaCl solution on days 5 p.i. (F1) Brain tissue taken from a mink died from K. pneumoniae-SD-12 infection on days 5 p.i., characterized by light bleeding and edema of the brain breakage. (F2) Brain tissue taken from a mink died from K. pneumoniae-SD-21 infection on days 5 p.i., characterized by light bleeding and edema of the brain breakage. (F3) Brain tissue from a euthanized mink inoculated with 0.9% NaCl solution on days 5 p.i. HE stain. Original magnification was × 200 for all images.

Histopathologic appearance of tissues of the mink. (A) Lung tissue taken from a control mink on day 6 p.i. (B) Heart tissue taken from a control mink on day 6 p.i. (C) Lung tissue taken from a inoculated mink on day 6 p.i., characterized by large area of bleeding, thickening of the alveolar septa. (D) Heart tissue taken from a inoculated mink on day 6 p.i., characterized by infiltration of inflammatory cells. (E) Lung tissue taken from an exposure mink on day 6 p.i., characterized by slight thickening of the alveolar septa. (F) Heart tissue taken from an exposure mink on day 6 p.i., no obvious histologic lesions were found. HE stain. Original magnification was ×200 for all images.